Nobody was seriously injured during a train collision in Cape Town on Tuesday, the city's disaster management centre said.

"According to paramedics only one adult male sustained slight injuries and no fatalities have been recorded. The train was carrying approximately 500 passengers," spokesman Wilfred Solomons-Johannes said in a statement.

The passenger train en-route to Malmesbury from Cape Town collided with a stationary goods train near Fisantekraal shortly after 5pm.

"The paramedics will be assessing all the passengers that was on-board the trains for possible injuries. The situation is under control and does not require any further resources or disaster response teams."

Buses would take passengers to their destinations.

The Railway Safety Regulator would investigate.