Tshabalala-Msimang was admitted to the private Folateng-wing at the Charlotte Maxeke hospital in Johannesburg, the Rapport newspaper reports.
Her illness is related to her first transplant.
Tshabalala-Msimang's specialist, Prof Jeff Wing, said that her body is rejecting the liver she received in 2007.
Tshabalala-Msimang received the liver transplant in 2007 from a teenage suicide victim.
“Every liver transplant must first be approved by a panel of specialists. Her case would have to have strong motivation because it is extremely unusual for anyone to have the chance of a second transplant,” Wing added.
After the transplant, controversy erupted when the Sunday Times reported that the cirrhosis which necessitated her first liver transplant was alcohol induced. It also alleged that Tshabalala-Msimang had continued drinking alcohol even after receiving a new liver.
Dukeboy