Promoter Don King announced the fight on Wednesday, along with the main event between former Cuban Olympic gold medalist Odlanier Solis and Ray Austin in a WBC heavyweight eliminator.
The winner of that fight will earn a mandatory shot at Vitali Klitschko.
The fights will be held on Dec. 17 in Miami at AmericanAirlines Arena.
Cloud is coming off a narrow title defense against Glen Johnson in August, while Zuniga will be fighting at 175 pounds (79 kilograms) for the first time.
Three of his four losses were in super middleweight title fights, and the other to former middleweight champion Kelly Pavlik.
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