Springbok women's flank Lamla Momoti was forced to withdraw from the team's opening Women's Rugby World Cup clash against Australia on Friday, the SA Rugby Union announced.
Rachelle Geldenhuys, who made her Test debut against France in July, will replace the injured Momoti in the starting XV.
The Test will be hosted at the French Rugby Federation in Marcoussis at 3.45pm on Friday.
Momoti injured her knee during training on Thursday and had a late fitness test to give her sufficient time to recover from the injury. She did not recover fully and had to withdraw from the squad.
South African women's team: Cindy Cant, Veroeshka Grain, Benele Makwezela, Lorinda Brown, Phumeza Gadu, Zenay Jordaan (vice-captain), Tayla Kinsey, Mandisa Williams (captain), Vuyolwethu Vazi, Rachelle Geldenhuys, Cindy Booi, Celeste Adonis, Cebisa Kula, Denita Wentzel, Asithandile Ntoyanto. Replacements: Thantaswa Macingwana, Nwabisa Ngxatu, Andrea Mentoor, Shona-Leah Weston, Fundiswa Plaatjie, Zandile Nojoko, Siviwe Basweni.