Protesting students are blocking university entrances and "engaging in acts of intimidation to disrupt classes and operations", the Nelson Mandela University said on Wednesday.
The university laid a charge at the Humewood police station in Port Elizabeth earlier Wednesday.
"Management is currently reading the interdict to protesting students, following which it will be enacted," the university said in a statement on its Twitter account.
"Staff and students are advised to exercise care and caution to ensure their safety. Management is presently engaging with the issues."
The Sasco-aligned protesters are demonstrating against a shortage of accommodation and issues around financial allowances.
