Local A-listers set to take part include Cassper Nyovest, Black Coffee, Nomzamo Mbatha and Sho Madjozi.
They will join international stars like Chris Martin, Lizzo, Taylor Swift, Sam Smith, Alicia Keys, Amy Poehler, Awkwafina, Camila Cabello, Celine Dion, Ellen DeGeneres, Jennifer Lopez, LL Cool J, Lupita Nyong'o, Matthew McConaughey, Oprah Winfrey, Pharrell Williams, Shawn Mendes and Usher.
Wondering where you can watch it? Starting at 8pm, it'll be live-streamed on TimesLIVE and various social media platforms, and broadcast on Vuzu (DStv channel 116).