The Johannesburg Road Agency has said the M1 southbound will be reduced to two lanes from the Killarney area to the St Andrews off-ramp.
Residents of the Rosebank and Houghton areas looking to travel south will have to find alternative routes‚ as the southern on-ramp onto the M1 from Oxford road will be closed at Ettrick road.
Councillor Christian Walters had said the rehabilitation was important due to dangerous flooding on the double-decker section of the M1.
"This section of the freeway is a key arterial route through the heart of Johannesburg and daily carries approximately 80‚000 private cars‚ commercial traffic and public transport...all vital to the growth of southern-most important economic hub‚" Walters said.
Certain lanes on the M1 double-decker section will be closed until July 6‚ 2017‚ on weekdays between 9.30am and 2.30pm.