When playing against a side as good as Pep Guardiola's Manchester City, Tottenham must take whatever edge they can get, and it turns out a Monday kick-off could be the advantage they're after.
While a tough day for most, Spurs have won seven and lost none of their last nine Premier League games played on Monday, with their last loss dating back to April 2012.
Tottenham also have home ground advantage and have developed a strong record at Wembley of late, having lost just two of their past 21 Premier League matches at the venue.
In addition, the news that midfielder Dele Alli could return for tomorrow's clash has added further ammunition to the Spurs cause.
Alli has been sidelined with a hamstring injury since Tottenham's League Cup win over Watford on September 26 and they could go above City with a fifth successive league victory, and the possible return of Alli would be a boost against Guardiola's in-form side.
Unfortunately for Mauricio Pochettino's men, that's where the good news ends - with Guardiola's side in stunning form. Unbeaten in 15 straight Premier League matches, conceding just six goals across that span, City are on a roll and haven't shown any real signs of slowing this season.
The return of Kevin De Bruyne adds fuel to that fire.
City also boast a very strong record against Spurs, having won 10 of their last 15 encounters and have taken a liking to playing in London - winning their past four games in the capital.
Guardiola and Pochettino are two of the finest managers in world football at the moment, but it's the Spaniard with a very real edge over his Argentine counterpart. The City mastermind has lost just two of his past 13 matches against Pochettino and is closing in on a third straight win against him.
Though Spurs have shown impressive durability in the league lately, they will need to be at their most steadfast to deny the champions and league leaders a victory.
After a 2-1 home defeat by Liverpool early last month, Spurs have ground out four league wins in a row, while missing key players such as Dele Alli and Christian Eriksen. They often rode their luck in those victories, however, and last Saturday's 1-0 win at West Ham United was in large part down to the excellence of goalkeeper Hugo Lloris.
Guardiola has, however, warned his players they risk losing their place in his first-team squad if they react poorly to being left out of the starting line-up.
De Bruyne's return, ahead of schedule, from a knee ligament injury means that competition for places has never been more keen among City's glittering, star-studded squad.
The strength in depth at Guardiola's disposal means that senior players will inevitably be disappointed as they spend time on the bench or out of the matchday squads completely.
But, while the City manager has been pleased so far by the response of those left on the sidelines, he has warned that anyone guilty of sulking, or responding negatively, will harm their chances of a recall.
"It's always a problem. I am unfair," Guardiola told a news conference on Friday. "The guys who don't play deserve to play, it's always like this. When they are training in a bad way they are out of the selection for themselves."
But big-money signings such as Leroy Sane, Nicolas Otamendi and Gabriel Jesus have struggled for significant minutes in City's unbeaten start to the Premier League season while promising youngster Phil Foden has seen scarce game time off the bench.
With the top five in the Premier League separated by two points only it has led Guardiola to conclude that Tottenham, along with Liverpool, Chelsea and Arsenal, are all genuine contenders to displace City in a five-horse title race.
City's fortunes contrast starkly with their rivals Manchester United, who are already nine points adrift of City in 10th place and welcome an in-form Everton side to Old Trafford today.
Another meek performance in losing for the fifth time this season in midweek to Juventus has put Jose Mourinho's position as United manager back in peril ahead of in-form Everton's visit.
On a run of just one win in seven games in all competitions, United already look out of the title race, nine points adrift of Manchester City and Liverpool, but are also in danger of missing out on the top four with Chelsea, Arsenal and Tottenham also just two points off the top before the latest round of matches.
United's Romelu Lukaku will line up against his former club having not found the net in his last eight matches in all club competitions. In the week, Mourinho backed the Belgian to rediscover his scoring touch soon.
While former Chelsea boss Mourinho needs to turn around United's season, the new man in charge at Stamford Bridge, Maurizio Sarri, could hardly have made a better start. If third-placed Chelsea avoid defeat at Burnley today, he will become the club's first manager to go undefeated in his first 10 Premier League games.
At the same time, London rivals Arsenal will be going for their 11th win in a row in all competitions when they travel to a Crystal Palace side struggling to find the net...