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Thirteen people were injured when a minibus taxi drove into a truck on the N2 near Port Shepstone, paramedics said on Sunday.
"Thirteen taxi commuters were injured after a taxi rear-ended a truck on the N2 North between Port Shepstone and Hibberdene this afternoon," said Netcare 911 spokesman Chris Botha in a statement.
Five people sustained serious injuries and eight minor injuries.
They were treated on the scene before being transported to a hospital in Port Shepstone.
The cause of the accident was being investigated.