Two trucks collided head-on in an accident on the N1 between Beaufort West and Three Sisters in the early hours on Wednesday.
Four people have been reported dead, said Ntomboxolo Makoba-Somdaka, spokesperson for Western Cape minister of transport and public works, Bonginkosi Madikizela.
Both vehicles caught fire.
The road was temporarily closed.
Motorists were advised to use the alternative route Aberdeen-Graaff Reinet-Murraysburg and back onto the N1.
One lane has since been reopened.
TimesLIVE
