Woman interrupted

25 March 2015 - 02:11 By ©The New York Times

Two years ago I wrote about my choice to have a preventive double mastectomy. A simple blood test had revealed that I carried a mutation in the BRCA1 gene. It gave me an estimated 87% risk of breast cancer and a 50% risk of ovarian cancer. I lost my mother, grandmother and aunt to cancer.I wanted other women at risk to know about the options. I promised to follow up with any information that could be useful, including about my next preventive surgery and the removal of my ovaries and fallopian tubes.I had been planning this for some time. It is a less complex surgery than the mastectomy, but its effects are more severe. It puts a woman into forced menopause. So I was preparing myself physically and emotionally, discussing options with doctors, researching alternative medicine, and mapping my hormones for oestrogen or progesterone replacement. But I felt I still had months to make the date.Two weeks ago my doctor called with blood-test results. "Your CA-125 is normal," he said. I breathed a sigh of relief. That test measures the amount of the protein CA-125 in the blood, and is used to monitor ovarian cancer. I have it every year because of my family history.But that wasn't all. "There are a number of inflammatory markers that are elevated, and taken together they could be a sign of early cancer." I took a pause. "CA-125 has a 50% to 75% chance of missing ovarian cancer at early stages," he said. He wanted me to see the surgeon immediately to check my ovaries.I went through what I imagine thousands of other women have felt. I told myself to stay calm, to be strong, and that I had no reason to think I wouldn't live to see my children grow up and to meet my grandchildren.I called my husband in France. He was on a plane within hours. The beautiful thing about such moments in life is that there is so much clarity. You know what you live for and what matters. It is polarising, and it is peaceful.That same day I went to see the surgeon. I had last seen her the day my mother passed away, and she teared up when she saw me: "You look just like her." I broke down. But we smiled at each other and agreed we were there to deal with any problem, so "let's get on with it".Nothing in the examination or ultrasound was concerning. I was relieved that if it was cancer it was most probably in the early stages. If it was somewhere else in my body, I would know in five days. I lived those five days in a haze.The day of the results came. The PET/CT scan looked clear, and the tumour test was negative. I was full of happiness, although the radioactive tracer meant I couldn't hug my children. There was still a chance of early-stage cancer, but that was minor compared with a full-blown tumour. To my relief, I still had the option of removing my ovaries and fallopian tubes and I chose to do it.I did not do this solely because I carry the BRCA1 gene mutation, and I want other women to hear this. A positive BRCA test does not mean a leap to surgery. I have spoken to many doctors, surgeons and naturopaths. There are other options. Some women take birth control pills or rely on alternative medicines combined with frequent checks. There is more than one way to deal with any health issue. The most important thing is to learn about the options and choose what is right for you personally.In my case, the Eastern and Western doctors I met agreed that surgery to remove my tubes and ovaries was the best option, because, on top of the BRCA gene, three women in my family have died from cancer. My doctors indicated I should have preventive surgery about a decade before the earliest onset of cancer in my female relatives. My mother's ovarian cancer was diagnosed when she was 49. I'm 39.Last week, I had the procedure: a laparoscopic bilateral salpingo-oophorectomy. There was a small benign tumour on one ovary, but no signs of cancer in any tissue.I have a little clear patch that contains bio-identical oestrogen. A progesterone IUD was inserted in my uterus. It will help me maintain a hormonal balance, but more importantly it will help prevent uterine cancer. I chose to keep my uterus because cancer there is not part of my family history.It is not possible to remove all risk, and the fact is I remain prone to cancer. I will look for natural ways to strengthen my immune system. I feel feminine, and grounded in the choices I am making for myself and my family. I know my children will never have to say: "Mom died of ovarian cancer."Regardless of the hormone replacements I'm taking, I am now in menopause. I will not be able to have any more children, and I expect some physical changes. But I feel at ease with whatever will come, not because I am strong but because this is a part of life. It is nothing to be feared.I feel deeply for women for whom this moment comes very early in life, before they have had children. Their situation is far harder than mine. I found out that there are options for women to remove their fallopian tubes but keep their ovaries, and so retain the ability to bear children and not go into menopause. I hope they can be aware of that.It is not easy to make these decisions. But it is possible to take control and make choices that are right for you. Knowledge is power. Jolie is an actress, film director and special envoy of the UN High Commissioner for Refugees..

There’s never been a more important time to support independent media.

From World War 1 to present-day cosmopolitan South Africa and beyond, the Sunday Times has been a pillar in covering the stories that matter to you.

For just R80 you can become a premium member (digital access) and support a publication that has played an important political and social role in South Africa for over a century of Sundays. You can cancel anytime.

Already subscribed? Sign in below.



Questions or problems? Email helpdesk@timeslive.co.za or call 0860 52 52 00.