The chase followed the murder of a 46-year-old man at a Kenilworth petrol station, which Traut said was gang-related.
CCTV footage of the attack shows the man - who has not yet been named by police - waiting at a petrol pump in a blue BMW at 6.45pm.
Two gunmen run up and the first fires several shots at the driver from the passenger side of the car.
The second gunman fires from the driver’s side, then approaches the driver’s open window and continues firing at close range. The two men then run off out of view.
The four suspects, aged 20, 25, 29 and 35, were due to appear in Wynberg Magistrate's Court on Monday charged with murder.
"Our investigation has led us to believe that the four suspects have links with a local gang in the Cape Flats and we have reasons to believe that the attack was a gang-related crime," said Traut.
"We would like to know the motive for the killing and that part is still under investigation."