Abu Dhabi-owned The National newspaper, quoting a Dubai Civil Defence spokesperson, said the blast had caused a blaze that damaged the ground floor of the building. The fire was controlled within 33 minutes, it added.
In Abu Dhabi, the blast hit KFC and Hardees restaurants on the city's Rashid bin Saeed Street, the National reported, adding that other retail outlets were also damaged.
Abu Dhabi police said the explosion caused several minor and moderate injuries, and residents of the building and surrounding areas were evacuated.
Photos published on social and local media showed extensive damage to the two restaurants with a white plume of smoke rising from the ground floor of the building.
Rashid Saeed Street is also known as the airport road, where top aides to US President Donald Trump and Israeli Prime Minister Benjamin Netanyahu are expected to land later on Monday, in a historic trip between Israel and another Arab country.