Reporting the incident on its official Facebook page, the Orange Police Department said its officers arrived at about 5:30pm local time “as shots were being fired and located multiple victims at the scene including fatalities”.
The police statement said an “officer-involved shooting” had occurred and that the situation had since been “stabilised” with no further threat to the public.
KNBC-TV reported the shooting erupted at a business complex in Orange, a city about 30 miles southeast of downtown Los Angeles. The television station and CNS reported that the dead included a child. Various news outlets also reported that the shooter was among those injured.
The violence marked the third deadly mass shooting in the US over the past two weeks.
Eight people were shot to death by a gunman who went on a rampage at three day spas in the Atlanta area on March 16. And 10 people were killed on March 22 when a man opened fire at a supermarket in Boulder, Colorado. The lone suspects in both those shootings were arrested.
Reacting on Twitter to Wednesday's events in Orange, California governor Gavin Newsom called the latest bloodshed “horrifying and heartbreaking”.