ER24 paramedics said the all four of the victims were in their 30s.
Spokesperson Russel Meiring gave further details on the wounds suffered by the victims.
"One man had a gunshot wound to his head while the other man had a gunshot wound in his chest," Meiring said.
"Nothing could be done for them and they were declared dead," he added.
Meiring said the two shot women were in "critical" condition. Both had gunshot wounds in the abdomen and one of the women was also shot in the leg.
"At this moment, it is unknown as to the number of suspects involved, or the motive for this incident as nothing was taken at the place," Mtshali said.
He called on anyone with information to come forward.