Form and history make this latest iteration of the North London derby a tough one to predict and it could come down to one man to make the difference.
While Tottenham boast Harry Kane - a man who has scored in six of his last seven Premier League clashes against Arsenal - and the in-form Son Heung-min, who continues to dazzle, while the Gunners have a ruthless Pierre-Emerick Aubameyang up their sleeve.
Current joint-top scorer in the competition, the 29-year-old attacker has remarkably scored with each of his last eight shots on target in the Premier League with West Ham's Lukasz Fabianski the last keeper to make a save against him back in August.
While he has completely missed one or two sitters during that span, Aubameyang is as deadly as they come in front of goal with his sheer pace allowing him to get in perfect positions for unstoppable finishes and he could very easily be the player to decide an unpredictable encounter.
On paper, Arsenal can be considered slight favourites on home soil with Spurs winning just one of their past 25 away Premier League matches against the Gunners - who have in turn scored in 22 straight North London derbies at home.
Arsenal have, however, won just one of their last eight Premier League clashes against Tottenham with Spurs' strong away form this season seeing them win seven of their eight games played on the road.
Just three points separate the two sides on the table and though the Gunners sit two places behind Tottenham in fifth, they are unbeaten in their past 11 league matches.
Though enjoying a solid start to life at the Emirates, Unai Emery must defy a trend that's seen just two of the past nine Arsenal managers win their first North London derbies.
But the one man who's really hoping to make an impact is Lucas Moura, who'll want to remind Arsenal manager Unai Emery of his quality.
Moura played for the Arsenal head coach at Paris Saint-Germain before falling out of favour in France and moving to Tottenham Hotspur in January.
The Brazilian, who has impressed for Spurs this season after a slow start to his career in north London, said in the summer that his final campaign at PSG was the "worst seven months of my life" after he was dropped from Emery's side.
Speaking after Spurs defeated Inter Milan to keep alive their hopes of reaching the knockout stages of the Champions League, Moura said Emery never told him why he was not being selected in Paris.
"I need to respect the decision of the coach," Moura said. "I know that it's difficult for him because he needs to choose 11 players to play. I don't like to look behind. I like to look forward to what I can do, what I can win. I have nothing against Unai, I respect him. He is a very good coach."
Asked if today's derby is a chance to show Emery that he is capable of starring for a big team, Moura added: "I try to show it, him, at Spurs. To enjoy the life because I love to play football. I forget the last five or six months that I had at PSG."
Meanwhile, Seamus Coleman says in-form Everton need to do their talking on the pitch today when they take on Liverpool looking for a first win in a Merseyside derby at Anfield this century.
Liverpool have dominated the derby at all venues in recent years with Everton winless in 17 matches in all competitions since a 2-0 Premier League victory in 2010.
On the other side of Stanley Park from their Goodison home, however, Everton supporters have not had a victory to celebrate since Kevin Campbell's goal gave them a 1-0 league win in September 1999.
Liverpool manager Jürgen Klopp issued a warning ahead of the 232nd Merseyside derby by branding Everton "a different cup of tea" this season...